Department of Chemistry
Dr. Shakir Ahamad
|Designation :||Assistant Professor (Contractual)|
|Thrust Area :||Organic Synthesis, Bio-Organic and Medicinal Chemistry, Drug Design and Discovery, Formulation, Targeted Drug Delivery, Design and Synthesis of Drug Delivery Vehicles, Host-Guest Chemistry|
|Address :||D/O Chemistry, AMU, Aligarh, 202002 (U.P.), India|
|Joining Date :||2019-08-02|
|Nature of association :||Contractual|
|Time Table :||Click to View|
|Download :||Click here to download study materials|
|Online :||Click here to View Video Lectures|
Dr. Shakir was born and raised in Saharanpur, Uttar Pradesh. He graduated with a Bachelor of Science in Chemistry from Kurukshetra University in 2011 and obtained his M.Sc. degree in Organic Chemistry from Aligarh Muslim Universit in 2013. During his post-graduation, he qualified NET (JRF) and GATE exam. Later, he joined Dr. Kishor Mohanan's research group at CSIR-Central Drug Research Institute, Lucknow, and completed his Ph.D. on Domino reactions employing diazo compounds: efficient access to novel N-heterocycles. He has been awarded JRF and SRF fellowship from UGC, New Delhi during his doctoral studies. During his tenure, he worked as a synthetic organic and medicinal chemist. Dr Ahamad has significantly contributed to basic research based on designing new domino multi-component reactions using diazo compounds, enabling the safe use of these reagents in the preparation of important N-heterocycles. Under the CSIR- Central Drug Research Institute program for drug discovery, he worked on the design, discovery and pre-clinical development of new small molecule therapeutics with special emphasis on HIV, parasitic diseases, and Hyperlipidemia. Some of his designed molecules showing very good biological activities against various diseases especially, the pre-clinical development of aminopyridine derived PCSK-9 inhibitors (CDRI-S-017-0594) for anti-hyperlipidemic activity with % Antihyperlipidemic Activity = 112.65 and, amino propanols as anti-Malarial agents (Pf IC50 (3D7 cells) = 70 nm, Pf IC50 (K1cells) = 40 nm, CC50 = 78.9 μM). He also worked on the design and the synthesis of nucleosides as anti-HIV agents.
After completion of his Ph.D., he joined Dr. Tejender S. Thakur's research group at CSIR-CDRI, where he worked on the design and synthesis of new drug carriers for drug delivery. During this project, he worked on the development of the novel supramolecular formulation of CDK4/6 inhibitors (Palbociclib and Ribociclib, which are widely employed in the treatment of breast cancer in the postmenopausal women). He also formulated the CSIR-CDRI potent anti-breast cancer lead molecule, CDRI-S-011-1559 to a higher soluble and stable solid form. CSIR-Central Drug Research Institute awarded him incentive award in chemical sciences twice, in 2017 and 2020.
He subsequently joined Aligarh Muslim University in 2019 as an Assistant Professor. His current research interests centered around finding new chemical entities in treating HIV, Malaria, and Hyperlipidemia. He also works on the design and development of new domino multi-component reactions for the synthesis of medicinally important heterocyclic compounds. His other research interests are Organic Synthesis, Bio-organic and Medicinal Chemistry, Targeted Drug Delivery, Design and Synthesis of Drug Delivery Vehicles, Formulations Strategies to Improve the Oral Bioavailability of Poorly Absorbed Drugs, and the Host-guest Chemistry. His findings are well documented in peer-reviewed research journals such as Organic Letters, organic and biomolecular chemistry, Asian Journal of Organic Chemistry, etc.
1. Silver-Catalyzed Three-Component Route to Trifluoromethylated 1,2,3-Triazolines Using Aldehydes, Amines, and Trifluorodiazoethane. A. Kumar, S. Ahamad, R. Kant, K. Mohanan. Org. Lett., 2019, 21, 2962. https://pubs.acs.org/doi/10.1021/acs.orglett.9b01159
2. Metal-Free three-component assembly of fully-substituted 1,2,3-triazoles Ahamad, S.; K.; Kumar A.; Kant, R.; Mohanan, K. Asian J. Org. Chem, 2018, 7, 1698. https://onlinelibrary.wiley.com/doi/abs/10.1002/ajoc.201800340
3. Base-mediated 1,6-conjugate addition reaction of Seyferth-Gilbert reagent to para-quinone methides A. K. Gupta, S. Ahamad, R. Kant, K. Mohanan Org. Biomol. Chem. 2018, 16, 4623. https://pubs.rsc.org/en/content/articlelanding/2018/ob/c8ob01017j#!divAbstract
4. Three-component synthesis of 3,4-disubstituted pyrazoles using diazosulfone as a diazomethane surrogate. S. Ahamad, R. K. Patidar, A. Kumar, R. Kant, K. Mohanan, ChemistrySelect 2017, 2, 11995. https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201702384
5. Three-component domino HWE olefination/1,3-dipolar cycloaddition/oxidation strategy for the rapid synthesis of trisubstituted pyrazoles. S. Ahamad, R. Kant, K. Mohanan, ChemistrySelect 2016, 1, 5276. https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201601113
6. Metal-Free three-component domino approach to phosphonylated triazolines and triazoles. S. Ahamad, R. Kant, K. Mohanan, Org. Lett. 2016, 18, 280. https://pubs.acs.org/doi/10.1021/acs.orglett.5b03437
7. Substrate-controlled product-selectivity in the reaction of the Bestmann–Ohira reagent with N-unprotected isatin-derived olefins. A. K. Gupta, S. Ahamad, E. Gupta, R. Kant, K. Mohanan, Org. Biomol. Chem. 2015, 13, 9783. https://pubs.rsc.org/en/content/articlelanding/2015/ob/c5ob01382h#!divAbstract
8. Domino reaction involving the Bestmann–Ohira reagent and α,β-unsaturated aldehydes: efficient synthesis of functionalized pyrazoles. S. Ahamad, A. K. Gupta, R. Kant, K. Mohanan, Org. Biomol. Chem. 2015, 13, 1492. https://pubs.rsc.org/en/content/articlelanding/2015/ob/c4ob02365j#!divAbstract